کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6807765 | 1433585 | 2013 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Detecting spatial memory deficits beyond blindness in tg2576 Alzheimer mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Detecting spatial memory deficits beyond blindness in tg2576 Alzheimer mice Detecting spatial memory deficits beyond blindness in tg2576 Alzheimer mice](/preview/png/6807765.png)
چکیده انگلیسی
The retinal degeneration Pde6brd1 (rd) mutation can be a major pitfall in behavioral studies using tg2576 mice bred on a B6:SJL genetic background, 1 of the most widely used models of Alzheimer's disease. After a pilot study in wild type mice, performance of 8- and 16-month-old tg2576 mice were assessed in several behavioral tasks with the challenge of selecting 1 or more task(s) showing robust memory deficits on this genetic background. Water maze acquisition was impossible in rd homozygotes, whereas Y-maze alternation, object recognition, and olfactory discrimination were unaffected by both the transgene and the rd mutation. Spatial memory retention of 8- and 16-month-old tg2576 mice, however, was dramatically affected independently of the rd mutation when mice had to recognize a spatial configuration of objects or to perform the Barnes maze. Thus, the latter tasks appear extremely useful to evaluate spatial memory deficits and to test cognitive therapies in tg2576 mice and other mouse models bred on a background susceptible to visual impairment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 34, Issue 3, March 2013, Pages 716-730
Journal: Neurobiology of Aging - Volume 34, Issue 3, March 2013, Pages 716-730
نویسندگان
Nour Yassine, Anelise Lazaris, Cornelia Dorner-Ciossek, Olivier Després, Laurence Meyer, Michel Maitre, Ayikoe Guy Mensah-Nyagan, Jean-Christophe Cassel, Chantal Mathis,