کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6809601 | 1433596 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tau acts as an independent genetic risk factor in pathologically proven PD
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Tau acts as an independent genetic risk factor in pathologically proven PD Tau acts as an independent genetic risk factor in pathologically proven PD](/preview/png/6809601.png)
چکیده انگلیسی
MAPT has been repeatedly linked with Parkinson's disease (PD) in association studies. Although tau deposition may be seen in PD, its relevance to the pathogenesis of the condition remains unclear. The presence of tau-positive inclusions is, however, the defining feature of progressive supranuclear palsy (PSP), which may often be clinically misdiagnosed as idiopathic PD. On a genetic level, variants in MAPT are the strongest risk factor for PSP. These facts raise the question whether the MAPT association in PD results from contamination with unrecognized cases of PSP. Using only neuropathologically proven PD, we show that the MAPT association remains and is independent of the PSP Association.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 33, Issue 4, April 2012, Pages 838.e7-838.e11
Journal: Neurobiology of Aging - Volume 33, Issue 4, April 2012, Pages 838.e7-838.e11
نویسندگان
Gavin Charlesworth, Sonia Gandhi, Jose M. Bras, Roger A. Barker, David J. Burn, Patrick F. Chinnery, Stephen M. Gentleman, Rita Guerreiro, John Hardy, Janice L. Holton, Andrew Lees, Karen Morrison, Una-Marie Sheerin, Nigel Williams, Huw Morris,