کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6810898 | 1433642 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of a NOS1 promoter repeat with Alzheimer's disease
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
The gene encoding NOS-I (NOS1) displays a complex transcriptional regulation, with nine alternative first exons. Exon 1c and 1f are the most abundant forms in the brain. A functional single nucleotide polymorphism (SNP) in exon 1c and a polymorphism in exon 1f, consisting of a variable number of tandem repeats (VNTR) originating short (S) and long (L) alleles, were studied in 184 patients with Alzheimer's disease (AD) and 144 gender- and age-matched controls. No differences were found for the Ex1c G-84A. The Ex1f-VNTR S allele was significantly more common in AD (55% versus 44%, PÂ =Â 0.009, ORÂ =Â 1.52) as was the S/S genotype (28% versus 14%, PÂ =Â 0.008; ORÂ =Â 2.37). The S allele showed a highly significant interaction with the ApoE É4 allele (OR: 10.83). Therefore, short alleles of the NOS1 exon 1f-VNTR are likely to be susceptibility factors for AD, and interact with the É4 allele to markedly increase the AD risk.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 29, Issue 9, September 2008, Pages 1359-1365
Journal: Neurobiology of Aging - Volume 29, Issue 9, September 2008, Pages 1359-1365
نویسندگان
Daniela Galimberti, Elio Scarpini, Eliana Venturelli, Alexander Strobel, Sabine Herterich, Chiara Fenoglio, Ilaria Guidi, Diego Scalabrini, Francesca Cortini, Nereo Bresolin, Klaus-Peter Lesch, Andreas Reif,