کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6863376 677387 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Classical conditioning of motor responses: What is the learning mechanism?
ترجمه فارسی عنوان
تهویه مطبوع کلاسیک موتور: مکانیسم یادگیری چیست؟
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر هوش مصنوعی
چکیده انگلیسی
According to a widely held assumption, the main mechanism underlying motor learning in the cerebellum, such as eyeblink conditioning, is long-term depression (LTD) of parallel fibre to Purkinje cell synapses. Here we review some recent physiological evidence from Purkinje cell recordings during conditioning with implications for models of conditioning. We argue that these data pose four major challenges to the LTD hypothesis of conditioning. (i) LTD cannot account for the pause in Purkinje cell firing that is believed to drive the conditioned blink. (ii) The temporal conditions conducive to LTD do not match those for eyeblink conditioning. (iii) LTD cannot readily account for the adaptive timing of the conditioned response. (iv) The data suggest that parallel fibre to Purkinje cell synapses are not depressed after learning a Purkinje cell CR. Models based on metabotropic glutamate receptors are also discussed and found to be incompatible with the recording data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neural Networks - Volume 47, November 2013, Pages 81-87
نویسندگان
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