Two-stage continuous flow synthesis of epoxidized fatty acid methyl esters in a micro-flow system

• A new protocol combining transesterification with epoxidation was reported.
• Continuous synthesis and consumption of FAMEs without purification was realized.
• Online separation promoted by a novel oil–water separating device was conducted.
• Epoxide number can reach up to 5.52 within 12 min.

A new protocol combining transesterification reaction with epoxidation process was reported. Besides, a novel continuous extraction device was employed in the integrated process to realize the automatic continuous flow synthesis of epoxidized fatty acid methyl esters (FAMEs). Furthermore, a capillary column containing desiccants was used in the post-processing, leading to dry product.

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