کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6874342 1441159 2018 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Investigating the use of Boolean networks for the control of gene regulatory networks
ترجمه فارسی عنوان
بررسی استفاده از شبکه های بولین برای کنترل شبکه های نظارتی ژنی
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نظریه محاسباتی و ریاضیات
چکیده انگلیسی
The behaviour of biological cells emerges from complex patterns of interactions between genes and their products, known as gene regulatory networks (GRN). An important aim of biology is to control the dynamics of GRNs, in order to push a cell towards or away from certain behaviours. This could potentially be done by coupling a synthetic GRN to an existing biological GRN. In this work, we use Boolean networks, a methodology for modelling and simulating GRNs, to investigate the potential for doing this. Our results demonstrate that Boolean networks can be optimised to control other Boolean networks, and that the approach scales well as the target network size increases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Computational Science - Volume 26, May 2018, Pages 147-156
نویسندگان
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