Homology modeling, molecular dynamics, and site-directed mutagenesis study of AlkB human homolog 1 (ALKBH1)

- Homology modeling is used to predict the full structure of the ALKBH1 protein.
- Disulfide bonds and a zinc finger domain in the structure of ALKBH1 are proposed.
- Mutagenesis is performed on residues predicted to form disulfide bonds/zinc finger.
- Environment of residues important for lyase function is analyzed.