Multi-generational pharmacophore modeling for ligands to the cholane steroid-recognition site in the β1 modulatory subunit of the BKCa channel

- Six pharmacophore models for the BKCa-β1 site have been evaluated against a common test set.
- The top model identified thousands of candidates BKCa activators from the PubChem database.
- Two of eight experimentally screened compounds were confirmed as BKCa activators.