کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6877739 692958 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multivariate SAR and QSAR of cucurbitacin derivatives as cytotoxic compounds in a human lung adenocarcinoma cell line
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
Multivariate SAR and QSAR of cucurbitacin derivatives as cytotoxic compounds in a human lung adenocarcinoma cell line
چکیده انگلیسی

- Cucurbitacins are natural products known for their several pharmacological properties.
- A data set with 43 cucurbitacins derivatives was used for a SAR/QSAR study.
- The cytotoxicity of each derivative in A549 cell line was assayed.
- Both the models presented good statistical quality.
- The models indicate that the cytotoxicity may be related to electrophilic attack.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Graphics and Modelling - Volume 48, March 2014, Pages 70-79
نویسندگان
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