کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
687949 | 889374 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Recrystallization of pharmaceuticals using the batch supercritical anti-solvent process
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
تکنولوژی و شیمی فرآیندی
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چکیده انگلیسی
Recrystallization of five pharmaceutical compounds using the batch supercritical anti-solvent (SAS) process was investigated in this study. The operation pressure was determined to be in the feasible region using the equation of state method. After the batch SAS process, significant modification of the crystal habits was observed from the SEM images. The recrystallized pharmaceuticals maintained similar crystalline structures after the batch process, as determined from the XRD analysis, but weaker intensities were observed in the XRD patterns. One endothermic peak for mefenamic acid was shifted after the batch SAS process due to particle size reduction or change in crystal habits.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering and Processing: Process Intensification - Volume 48, Issue 1, January 2009, Pages 92–100
Journal: Chemical Engineering and Processing: Process Intensification - Volume 48, Issue 1, January 2009, Pages 92–100
نویسندگان
Chie-Shaan Su, Muoi Tang, Yan-Ping Chen,