کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
688185 889399 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Study on the reactive extraction and stripping kinetics of certain β-lactam antibiotics
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی تکنولوژی و شیمی فرآیندی
پیش نمایش صفحه اول مقاله
Study on the reactive extraction and stripping kinetics of certain β-lactam antibiotics
چکیده انگلیسی

The extraction equilibrium and stripping of certain β-lactam antibiotics such as 7-aminocephalosporanic acid (7-ACA), 7-aminodeacetoxy cephalosporanic acid (7-ADCA), 6-aminopenicillanic acid (6-APA), cephalosporin-C (CPC) and cephalexin from aqueous solution of phosphate and carbonate buffers were studied with Aliquat-336 (tricaprylylmethylammonium chloride) dissolved in n-butylacetate as the solvent over an aqueous phase pH range of 5–10. The extraction equilibrium constant Kp was found to increase with aqueous phase pH, which is attributed to the increase in ionisation of the β-lactam. A systematic study on kinetic of stripping or re-extraction of 7-ADCA and cephalexin from the extracted phase was carried out using an aqueous solution of citrate buffer at different pH values and was found to be pH dependent which is also attributable to ionisation behaviour of the β-lactams. Such observation is considered important, as re-extraction at an appropriate pH value is possible. The rate of stripping was found to be weakly dependent on Cl− concentration of the aqueous phase and the same was analysed with a simple mass transfer model based on film theory.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering and Processing: Process Intensification - Volume 47, Issue 1, January 2008, Pages 1–8
نویسندگان
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