کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6890967 | 1445221 | 2018 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An object-oriented computational model to study cardiopulmonary hemodynamic interactions in humans
ترجمه فارسی عنوان
یک مدل محاسباتی شی گرا برای بررسی تعاملات همودینامیک قلب و ریه در انسان
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کلمات کلیدی
مدلسازی فیزیولوژیکی، مدل سازی شی گرا، تعاملات قلب و عروق، مدل سازی غیر خطی، تهویه مکانیکی، حجم ضربه،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
علوم کامپیوتر (عمومی)
چکیده انگلیسی
Background and objective: This work introduces an object-oriented computational model to study cardiopulmonary interactions in humans.Methods: Modeling was performed in object-oriented programing language Matlab Simscape, where model components are connected with each other through physical connections. Constitutive and phenomenological equations of model elements are implemented based on their non-linear pressure-volume or pressure-flow relationship. The model includes more than 30 physiological compartments, which belong either to the cardiovascular or respiratory system. The model considers non-linear behaviors of veins, pulmonary capillaries, collapsible airways, alveoli, and the chest wall. Model parameters were derisved based on literature values. Model validation was performed by comparing simulation results with clinical and animal data reported in literature.
Results:
The model is able to provide quantitative values of alveolar, pleural, interstitial, aortic and ventricular pressures, as well as heart and lung volumes during spontaneous breathing and mechanical ventilation. Results of baseline simulation demonstrate the consistency of the assigned parameters. Simulation results during mechanical ventilation with PEEP trials can be directly compared with animal and clinical data given in literature.
Conclusions:
Object-oriented programming languages can be used to model interconnected systems including model non-linearities. The model provides a useful tool to investigate cardiopulmonary activity during spontaneous breathing and mechanical ventilation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computer Methods and Programs in Biomedicine - Volume 159, June 2018, Pages 167-183
Journal: Computer Methods and Programs in Biomedicine - Volume 159, June 2018, Pages 167-183
نویسندگان
Chuong Ngo, Stephan Dahlmanns, Thomas Vollmer, Berno Misgeld, Steffen Leonhardt,