کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6898905 | 1446423 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Patulin interference with ATP binding cassette transferring auto inducer â2 in Salmonella typhi and biofilm inhibition via quorum sensing
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
علوم کامپیوتر (عمومی)
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چکیده انگلیسی
Salmonella typhi are Gram-negative pathogens that infect many hosts including humans and animals and cause diseases ranging from gastroenteritis and diarrhea to life-threatening systemic syndrome. Owing to the metabolic versatility, they will colonize as multi cellular aggregates on various surfaces to enhance the virulence by forming a biofilm in which bacterial cells are more resistant to antibiotics than planktonic cells. Quorum Sensing (QS) is a cell-to-cell communication mechanism in the bacterial system to coordinate group behaviors such as biofilms formation and virulence factors production. In QS system ATP Binding Cassette (ABC) transporter component, LsrA, plays a key role to transport autoinducer-2 (AI-2) to increase the cell density. In order to reduce biofilm formation, patulin was selected as a natural QS inhibitor and its function was studied by biofilm inhibitory assays. Significant differences in the spectroscopic values were obtained between antibiotic resistance of kanamycin (30â¯Î¼g/ml) and patulin (30â¯Î¼g/ml). Furthermore, to distinguish the molecular level interaction of LsrA, patulin and AI-2 were docked. Both the compounds were interact in the same pose with Glide score of â4.237â¯kcal/mol and â7.126â¯kcal/mol respectively. These results will suggest that patulin is the efficient Quorum Sensing Inhibitor to control biofilm formation in S.typhi.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Informatics in Medicine Unlocked - Volume 11, 2018, Pages 9-14
Journal: Informatics in Medicine Unlocked - Volume 11, 2018, Pages 9-14
نویسندگان
Princy Vijayababu, Gopinath Samykannu, Christian Bharathi Antonyraj, Jebastin Thomas, SundaraBaalaji Narayanan, Syed Ibrahim Basheer Ahamed, Shanmughavel Piramanayagam,