کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6898928 1446424 2018 43 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of curcumin loaded polymeric nanoparticles from crab shell derived chitosan for drug delivery
ترجمه فارسی عنوان
سنتز نانوذرات پلیمری حاوی کورکومین از کیتوزان مشتق شده از پوسته خرچنگ برای تحویل دارو
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر علوم کامپیوتر (عمومی)
چکیده انگلیسی
In this study, chitosan was derived from crab shell using two concentrations of hydrochloric acid i.e.1.5 M and 2 M HCl during demineralisation step. The obtained chitosan was utilised for synthesis of polymeric nanoparticles using sodium tripolyphosphate and barium chloride as chelators. The nanoparticles were encapsulated with hydrophobic curcumin and analysed for drug delivery invitro. Also, the synthesized nanoparticles were characterised by FTIR, SEM and AFM analysis and subjected for drug encapsulation efficiency, invitro drug release kinetics and controlled drug delivery studies in vitro against Pseudomonas aeruginosa. Barium chloride was found to produce spherical shaped drug loaded nanoparticles of size below 500 nm.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Informatics in Medicine Unlocked - Volume 10, 2018, Pages 159-182
نویسندگان
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