کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6920551 1447924 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechano-electric finite element model of the left atrium
ترجمه فارسی عنوان
مدل عنصر محدودی مکانیکی الکتریکی در دهلیز چپ
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
چکیده انگلیسی
Mechanical stretch plays a major role in modulating atrial function, being responsible for beat-by-beat responses to changes in chamber preload, enabling a prompt regulation of cardiac function. Mechano-electric coupling (MEC) operates through many mechanisms and has many targets, making it experimentally difficult to isolate causes and effects especially under sinus conditions where effects are more transient and subtle. Therefore, modelling is a powerful tool to help understand the role of MEC with respect to the atrial electromechanical interaction. We propose a cellular-based computational model of the left atrium that includes a strongly coupled MEC component and mitral flow component to account for correct pressure generation in the atrial chamber as a consequence of blood volume and contraction. The method was applied to a healthy porcine left atrium. Results of the strongly coupled simulation show that strains are higher in the areas adjacent to the mitral annulus, the rim of the appendage, around the pulmonary venous trunks and at the location of the Bachmann's bundle, approximately between the mitral annulus and the region where the venous tissue transitions into atrial. These are regions where arrhythmias are likely to originate. The role of stretch-activated channels was very small for sinus rhythm for the single cardiac beat simulation, although tension development was very sensitive to stretch. The method could be applied to investigate potential therapeutic interventions acting on the mechano-electrical properties of the left atrium.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers in Biology and Medicine - Volume 96, 1 May 2018, Pages 24-31
نویسندگان
, , , ,