کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6921754 | 864467 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Drug perfusion enhancement in tissue model by steady streaming induced by oscillating microbubbles
ترجمه فارسی عنوان
افزایش پرفیوژن دارو در مدل بافت توسط جریان ثابت ایجاد شده بوسیله نوسان مایعات حباب
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کلمات کلیدی
تحویل مواد مخدر، موج آکوستیک، میکروبابابل، جریان ثابت، مکانیک سیالات محاسباتی،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
نرم افزارهای علوم کامپیوتر
چکیده انگلیسی
Drug delivery into neurological tissue is challenging because of the low tissue permeability. Ultrasound incorporating microbubbles has been applied to enhance drug delivery into these tissues, but the effects of a streaming flow by microbubble oscillation on drug perfusion have not been elucidated. In order to clarify the physical effects of steady streaming on drug delivery, an experimental study on dye perfusion into a tissue model was performed using microbubbles excited by acoustic waves. The surface concentration and penetration length of the drug were increased by 12% and 13%, respectively, with streaming flow. The mass of dye perfused into a tissue phantom for 30Â s was increased by about 20% in the phantom with oscillating bubbles. A computational model that considers fluid structure interaction for streaming flow fields induced by oscillating bubbles was developed, and mass transfer of the drug into the porous tissue model was analyzed. The computed flow fields agreed with the theoretical solutions, and the dye concentration distribution in the tissue agreed well with the experimental data. The computational results showed that steady streaming with a streaming velocity of a few millimeters per second promotes mass transfer into a tissue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers in Biology and Medicine - Volume 44, 1 January 2014, Pages 37-43
Journal: Computers in Biology and Medicine - Volume 44, 1 January 2014, Pages 37-43
نویسندگان
Jin Sun Oh, Yong Seok Kwon, Kyung Ho Lee, Woowon Jeong, Sang Kug Chung, Kyehan Rhee,