Computing semantic similarity between biomedical concepts using new information content approach

Excerpt of MeSH taxonomy modeling the Information Contents (ICs) of the biomedical concepts “Antigens, Differentiation, T-Lymphocyte” (C1) and “Receptors, Interleukin-7” (C2). The IC is quantified using the ancestors' subgraph and the topological parameters (depth and descendants) of each ancestor. The lowest common subsumer (LCS) is the concept “Antigens, Differentiation”. The semantic similarity is computed using the IC(C1), IC(C2) and IC(LCS).127