Interaction of naproxen amphiphilic derivatives with biomembrane models evaluated by differential scanning calorimetry and Langmuir-Blodgett studies

► NAP-EDA-LAA10 and NAP-EDA-LAA14 prodrugs were obtained by conjugation of naproxen with lipoaminoacids through a diethylamine spacer. ► The interaction of NAP and prodrugs with biomembrane models was studied by differential scanning calorimetry and Langmuir-Blodgett techniques. ► The prodrugs showed a stronger interaction than naproxen with the biomembrane models.