Dynamic Transcriptomics: Transcriptomic Discovery of a Biological Multiple-Input Multiple-Output Heart Control Mechanism

We will recapitulate here a narrative in which we have just now been able to solve an important, frustrating and long standing puzzle as to how a brain control function of the heart is performed. The key to solving this puzzle has proved to be the acquisition of transcriptional profile data from single neurons. Analysis of this data forced a reconsideration of the fundamental structure of the brain control system. In turn, this reconsideration has led to subsequent re-ordering of a great deal of neuroanatomical and physiological data into a pattern that finally makes a great deal of sense.