Noise Propagation in Series Enzymatic Cascades

Series enzymatic cascades are ubiquitously found in signaling networks and act as key signal amplifiers. During signal transduction process, cell-to-cell variability or noise travels along with the signal and strongly affects the fitting response that the cells exhibit. Modulation of noise propagation through the enzymatic cascades can play a strong role in regulating cellular response. We find the conditions under which the noise propagation through the cascades is bounded. Using global sensitivity analysis, we quantified the dependence of these conditions on the system parameters and estimated the parameter range in which the system when operated will result in attenuation of noise propagation through the cascade.