miRNA Mediated Regulation of Rice (Oryza sativa) Genome

miRNAs play important roles in plant post-transcriptional gene regulation by targeting mRNAs through cleavage or repressing translation. Here, we have reconstructed genome scale level miRNA-miRNA co-targeting network of rice plant and identified several significant modules (high-density sub-graphs). Some of the modules are involved in multiple biological processes, while some are involved in a single biological process. The distribution of the out-going connectivities of co-target network can be approximated best by a power-law equation. We have also observed a wide variation in inter chromosomal regulation. The genes of chromosome 3 are highly targeted by the miRNAs synthesized from other chromosomes. The results presented here might provide a platform for testing the hypothetical role of co-targeting associations in rice post-transcriptional control.