Effect of Intra-Patient Variability on Personalized Parameters of Glucose-Insulin Dynamic Models for Exercise, Meal, and Insulin Interventions

The objective of this paper is to study the effect of intra-patient variations on the personalized parameters of the modified exercise minimal model by re-estimating them from the clinical data measured after several days of first estimation. Clinical data of eight type 1 diabetic children and adolescents have been used for this purpose. For the first estimation of 6 estimable parameters, clinical data collected during one of the visits have been employed. Subsequent re-estimation of parameters is accomplished using the second clinical visit data, which was collected after 7-35 days from the first visit. The results of re-estimation indicate that the estimable parameters corresponding to glucose-insulin compartments and meal absorption model are greatly affected by intra-patient variability in most of the patients, while the 2 estimable parameters corresponding to exercise compartments are least affected by intra-patient variations in 6 out of 8 patients.