کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7141882 | 1462035 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Electro-drawn polymer microneedle arrays with controlled shape and dimension
ترجمه فارسی عنوان
آرایه های میکروسکوپ پلیمر الکترو کشیده شده با شکل و اندازه کنترل شده
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Biodegradable polymer microneedles are recognized as a valuable route for transdermal drug delivery as well as for cutaneous treatments. According to the industrial needs, the present trend is to fabricate microneedles through stamp-less techniques. Electro-drawing has been recently proposed as an alternative fast and mild temperature strategy to the stamp based techniques for the fabrication of biodegradable polymer microneedles. However, previously presented electro-drawn microneedles were fabricated by a point-like thermal stimulation, thus, they could not be electro-drawn in parallel and displayed a pedestal at their basis. Here, we present a novel electro-drawing set up and strategy to parallelize the process and to avoid the pedestal at the microneedle basis. The new set-up is based on titanium micro-heaters integrated onto the pyroelectric substrate which is the electric field generator enabling the electro-drawing. The micro-heaters configuration has been chosen starting from numerical simulations to guarantee uniform heating on large areas, in contrast to the local heating by hot tip, allowing the generation of a uniform electric field which is a basic condition for an in parallel fabrication of microneedles. Additionally, thanks to the stronger electric field, it was possible to apply a double step electro-drawing, where the second step is carried out at higher distance in order to avoid microneedle shrinkage while avoiding further growing of the microneedles.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 255, Part 2, February 2018, Pages 1553-1560
Journal: Sensors and Actuators B: Chemical - Volume 255, Part 2, February 2018, Pages 1553-1560
نویسندگان
F. Ruggiero, R. Vecchione, S. Bhowmick, G. Coppola, S. Coppola, E. Esposito, V. Lettera, P. Ferraro, P.A. Netti,