Percutaneous fiber-optic biosensor for immediate evaluation of chemotherapy efficacy in vivo (Part II): In vitro and in vivo characterization

- Fiber-optic platform for non-homogeneously distributed biomarker sensing.
- FM 1-43 as optimal apoptotic activity indicator.
- Phospholipid conjugated marina blue (Mb) as optimal cell spatial distribution indicator in the vicinity of sensor probe.
- Indication of chemotherapy induced apoptotic activity by threshold value of FluoFM1-43/FluoMb.
- Signal input of personalized chemotherapy system.