کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7146357 | 1462082 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Polyoxometalate nanostructured gold surfaces for sensitive biosensing of benzo[a]pyrene
ترجمه فارسی عنوان
سطوح طلای نانو ساختار پلی ساکار آمیلات برای حساسیت زیست محیطی بنزو پریئن
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
We report the design of a polyoxometalate-nanostructured immunosensor for benzo[a]pyrene (B[a]P) detection. The organic-inorganic hybrid polyoxometalate (POM) (NBu4)3[PW11O39{(SiC6H4NH2)2O}] carrying two amine functions was covalently attached to a functionalized gold substrate to achieve a nanometric organization of amine groups at its surface. Pyrenebutyric acid (PBA) was subsequently grafted to amine groups to create the sensing layer. The detection of B[a]P in the indirect competitive format was carried out using a monoclonal anti-B[a]P antibody whose binding to the immunoprobe was monitored with a quartz crystal microbalance with dissipation measurement (QCM-D). The performances of the POM-nanostructured biosensor were compared to a reference sensor constructed from a cysteamine self-assembled monolayer. QCM-D measurements displayed significant input from POM-nanostructuration. Both the accessibility of the analogue on the surface and the analytical performances were enhanced showing a promising effect of this strategy of nanostructuration for the biosensing of small molecules.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 209, 31 March 2015, Pages 770-774
Journal: Sensors and Actuators B: Chemical - Volume 209, 31 March 2015, Pages 770-774
نویسندگان
Dimitri Mercier, Maroua Ben Haddada, Maria Huebner, Dietmar Knopp, Reinhard Niessner, Michèle Salmain, Anna Proust, Souhir Boujday,