کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7148201 1462103 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Large-scale arrays of nanomechanical sensors for biomolecular fingerprinting
ترجمه فارسی عنوان
آرایه های بزرگ در اندازه گیری از سنسورهای نانوموکانیک برای اثر انگشت بیوموکلئر
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
A review of activities involving the development of large arrays of nanomechanical resonators is presented. This review includes demonstration of the use of these arrays for the detection of biological targets. Both top-down and bottom-up approaches to the realization of such arrays were developed. Using a top-down approach, a nanomachining method for the fabrication of large arrays of doubly-clamped silicon carbonitride (SiCN) resonators with width as narrow as 16 nm and a yield approaching 100% was developed. The specific detection of protein-A using such resonator arrays functionalized with single domain antibody fragments (sdAb) was also demonstrated with femtogram-level mass sensitivity. A nano-imprinting based fabrication of these resonator arrays was also realized, opening up their potential for cost-effective manufacturing. On a bottom-up approach, resonant silicon nanowires were also produced using directed chemical vapor deposition methods. These bottom-up resonant nanowires were in turn successfully employed for the specific detection of streptavidin with attogram-level mass sensitivity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 187, October 2013, Pages 111-117
نویسندگان
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