کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7177780 | 1467052 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Microstructural model for cyclic hardening in F-actin networks crosslinked by α-actinin
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی مکانیک
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![عکس صفحه اول مقاله: Microstructural model for cyclic hardening in F-actin networks crosslinked by α-actinin Microstructural model for cyclic hardening in F-actin networks crosslinked by α-actinin](/preview/png/7177780.png)
چکیده انگلیسی
We think that the key to understand this stunning effect is the gelation process. To define it, the most relevant constituents are the chemical crosslinks - α-actinin -, the physical crosslinks - introduced by the entanglement of the semiflexible network - and the interaction between them. As a consequence of this interaction, a pre-stressed network emerges and introduces a feedback effect, where the pre-stress also regulates the adhesion energy of the α-actinin, setting the structure in a metastable reference configuration. Therefore, the external loads and the evolvement of the trapped stress drive the microstructural changes during the cyclic loading protocol. In this work, we propose a micromechanical model into the framework of nonlinear continuum mechanics. The mechanics of the F-actin filaments is modelled using the wormlike chain model for semiflexible filaments and the gelation process is modelled as mesoscale dynamics for the α-actinin and physical crosslink. The model has been validated with reported experimental results.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Mechanics and Physics of Solids - Volume 91, June 2016, Pages 28-39
Journal: Journal of the Mechanics and Physics of Solids - Volume 91, June 2016, Pages 28-39
نویسندگان
Horacio López-Menéndez, José Félix RodrÃguez,