An MPC-Based Approach to Robust Control of a Hypothalamic-Pituitary-Adrenal Axis Model

The hypothalamic-pituitary-adrenal (HPA) axis is a neuroendocrine control system regulating the stress response of the human body as well as affecting mood and cognition. HPA dysfunction has been associated with a variety of disorders including Fibromyalgia, and chronic fatigue syndrome (CFS). Recently, a lumped parameter model of the HPA axis which includes the effect of pharmacological agents has been proposed. In this work, an analysis of the HPA axis dynamics near rest points is used to develop an approach for robust control of the HPA system.