کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7211474 | 1469259 | 2017 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ultrasound assisted one pot expeditious synthesis of new pyrido[2,3-d]pyrimidine analogues using mild and inexpensive 4-dimethylaminopyridine (DMAP) catalyst
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The one-pot three-component reaction for the synthesis of pyrido[2,3-d]pyrimidine derivatives has been reported via initial Knoevenagel, subsequent addition and final heterocyclization of substituted aromatic aldehydes, cyanoacetamide and 6-aminouracil in N,N-dimethylformamide (DMF) solvent using 4-dimethylaminopyridine (DMAP) as new organocatalyst under ultrasound irradiation. The results showed that a series of aromatic aldehydes were successfully used to prepare the targeted pyrido[2,3-d]pyrimidine derivatives with good to excellent yields (81-93%) and there is no major effect on the yield of product by electron donating/withdrawing substituents. Short reaction time, environment friendly procedure, excellent yields, inexpensive and readily available catalyst are the advantages of this procedure. All synthesized compounds were characterized by IR, 1HNMR, 13CNMR and mass spectral data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Beni-Suef University Journal of Basic and Applied Sciences - Volume 6, Issue 3, September 2017, Pages 238-246
Journal: Beni-Suef University Journal of Basic and Applied Sciences - Volume 6, Issue 3, September 2017, Pages 238-246
نویسندگان
Ajmal R. Bhat, Gowhar A. Naikoo, Israr Ul Hassan, Rajendra S. Dongra, Tabassum Ara,