کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7213153 | 1469408 | 2015 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of degradable and bioactive composite as bone implants by incorporation of mesoporous bioglass into poly(l-lactide)
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Bioactive composites containing mesoporous bioglass (MBG) and poly(l-lactide) (PLLA) for bone regeneration were fabricated by solution casting method. The results showed that the compressive strength and hydrophilicity of the MBG/PLLA composites significantly improved with the increase of MBG content. In addition, the weight loss ratio of the composites in Tris-HCl solution was obviously enhanced with the increase of MBG content. Moreover, the composite containing MBG could compensate for the decrease of pH value by neutralizing the acidic products from PLLA degradation in the Tris-HCl solution. Furthermore, the MBG/PLLA composites could induce apatite formation on their surfaces after soaked into simulated body fluid (SBF), indicating good bioactivity. In cell culture experiments, the results showed that the composite could enhance cell attachment, proliferation and alkaline phosphatase activity (ALP) of MC3T3-E1 cells, and the improvements were dependent on the MBG content in the composites. In short, the MBG/PLLA biocomposites with improved properties of hydrophilicity, degradability, bioactivity, neutralizing acidic degradable products and good cytocompatibility would be a promising orthopedic implant material for bone repair application.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Composites Part B: Engineering - Volume 77, August 2015, Pages 454-461
Journal: Composites Part B: Engineering - Volume 77, August 2015, Pages 454-461
نویسندگان
Liehu Cao, Weizong Weng, Xiao Chen, Yueting Ding, Yonggang Yan, Haihang Li, Hao Zhao, Jung-Woog Shin, Jie Wei, Fang Ji, Jiacan Su,