Model-based operating control of the CSTB in order to improve its productivity

This paper presents on alternative method for improvement of the Continuous Stirred Tank Bioreactor (CSTB) productivity. Treating flow rate as an operating control and both substrate concentrations S1in and S2in as control variables, two different approaches are taken into account. The aim is to improve productivity of the CSTB. The first approach consists in finding such a substrate, which is characterized by a constant yield coefficient. The latter approach consists in adding another substrate to the system with self-sustained oscillations. In both cases there is a significant productivity improvement in steady states in comparison to the results obtained by A.Balakrishnan and R.Y.K.Yang in (Balakrishnan and Yang, 2002).