FRACTIONAL ORDER PROCESSING OF QUARTZ CRYSTAL MICROBALANCE BASED DNA BIOSENSOR SIGNALS

The working principle of quartz crystal microbalance (QCM) is based on the linear relationship between the change of frequency (Δf) and the change of mass on the crystal surface, as described in Sauerbrey equation. In present work, it is interesting to observe the oscillation characteristics of Δf and resistance (R) in the early period of single strand (ssDNA) immobilization and subsequent target DNA (tDNA) hybridization. Two fractional order signal processing techniques, namely, fractional Fourier transform (FrFT) and rescaled range statistical analysis (R/S analysis), are applied to analyze the QCM signals.