A MODEL OF FREE FATTY ACID KINETICS DURING INTRAVENOUS GLUCOSE TOLERANCE TEST

The dynamics of non-esterified free fatty acids (FFA) during modified intravenous glucose tolerance test (IVGTT) is studied. The first step is to formulate a physiological model suitable to describe FFA kinetics. A single compartment model is utilized, with FFA production controlled by insulin in a remote compartment and indirectly by intracellular glucose. Then, from the analysis of the experimental data, the kinetic parameters of the model are estimated using a population modelling approach and their dependence upon individual characteristics is investigated. The proposed model is a promising tool for investigating the relationship between glucose and lipid metabolism and their control by insulin.