کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
723359 | 892344 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: SYSTEM IDENTIFICATION OF PHOTOSENSITISER UPTAKE KINETICS IN PHOTODYNAMIC THERAPY SYSTEM IDENTIFICATION OF PHOTOSENSITISER UPTAKE KINETICS IN PHOTODYNAMIC THERAPY](/preview/png/723359.png)
This study presents the contributions of system identification techniques to the experimental modelling of photosensitiser uptake kinetics in photodynamic therapy. The experimental framework is limited to one cancer cell line (HT29-A4), one photosensitiser (Chlorin e6), one photosensitiser dose (5μg · ml–1), four albumin rates in a monolayer culture and eight measurements between 1h and 24h. Issues associated with this experimental modelling study are the deficiency of measurement points, low signal-to-noise ratios and 'poor' excitation signals (step signals). This paper deals with model structure selection, parameter estimation and parameter uncertainty description by probabilistic confidence regions. Moreover, an explicit relationship between the static gain of the estimated model and the albumin rate of the culture medium has been established.
Journal: IFAC Proceedings Volumes - Volume 39, Issue 18, 2006, Pages 195–200