NONLINEAR CONTROL OF HIV-1 INFECTION WITH A SINGULAR PERTURBATION MODEL

Using singular perturbation techniques, a nonlinear state-space model of HIV-1 infection, having as state variables the number of healthy and infected CD4+ T cells and the number of virion particles, is simplified and used to design a control law. The control law comprises an inner block that performs feedback linearizing of the virus dynamics and an outer block implementing an LQ regulator that drives the number of virion particles to a number below the specification. A sensitivity analysis of the resulting law is performed.