MODELLING DRUGS' PHARMACODYNAMIC INTERACTION DURING GENERAL ANAESTHESIA: THE CHOICE OF PHARMACOKINETIC MODEL

The effect of drugs' interaction on the brain signal Bispectral Index (BIS) is of great importance for an anaesthesia control drug infusion system. In this study, two renowned pharmacokinetic (PK) models for propofol are compared, in order to evaluate its influence on the performance/predictably of a drug interaction model for BIS, considering data of 45 patients. The model was fitted per patient during anaesthesia induction, and tested for prediction under surgery. The results showed that the choice of PK model had influence on the overall performance. In the prediction phase, only one PK model presented good results with small errors.