A FUZZY CLASSIFIER FOR DRUG SENSITIVITY IN SEPTIC PATIENTS DURING CARDIOPULMONARY BYPASS

A compartmental model is modified to simulate the capillary leak associated with Sepsis and Cardiopulmonary Bypass (CPB). This involves continuously updating the oncotic pressures with regard to the flows in and out of each compartment. As a result, it is possible to model the effects of administering fluids with different oncotic pressures on filtration. The model allows for simulated infusions of vasoactive and inotropic drugs with a range of sensitivities to these drugs, giving a comprehensive platform for testing various control strategies. Furthermore, a fuzzy logic based system is designed to classify drug responses according to sensitivity, using the drug input and mean arterial pressure (MAP) signals from the model. This can be used as part of a comprehensive drug decision support system to estimate initial sensitivity and/or detect long-term changes in drug sensitivity.