FROM METABOLIC NETWORKS TO MINIMAL DYNAMIC BIOREACTION MODELS

The paper deals with the design of minimal dynamic bioreaction models in the situation where (a) the model is based on the knowledge of a detailed underlying metabolic network, (b) measurements of extra-cellular species in the reactor are the only available measurements. A brief but rigorous presentation of the theory is first given. Then the approach is illustrated with the example of chinese hamster ovary cells cultivated in stirred flasks.