A ROBUST OUTPUT–FEEDBACK TREATMENT SCHEDULING FOR HIV-1

In this paper an anti–retroviral supply treatment scheduling for a dynamical model of the HIV-1 is proposed. This therapy design problem is approached from an equilibrium point stabilization perspective by viewing the drug treatment as a control law. The main feature of the proposed controller is threefold, namely: It exploits the natural properties, for stabilization purposes, of the HIV-1 model leading to a quite simple structure. It is an output–feedback scheme in the sense that for achieving the desired stability properties it is not required neither feedback nor estimation of the unmeasurable state. It is robust against both parametric and structural uncertainties. The usefulness of the presented control scheme is illustrated via numerical simulations.