SIMPLE 3D VASCULARIZATION MODELS FOR PERFUSION BIOREACTORS

Growing cells in a perfusion bioreactor for tissue engineering is challenging. Cell viability and distribution is determined by complex interactions between a medium flowing through a porous scaffold and cell growth. Using a mathematical model that includes oxygen transport by diffusion/convection and cell growth mechanism, the effect of simple vascularization within the scaffold is investigated. As an initial approximation, straight channels through the length of the scaffold are considered, with performance assessed using a systematic set of criteria. Results indicate the approach can inform the choice of suitable channel size and spacing, and should enable enhanced scaffold design.