MODELLING OF HIV INFECTION: VACCINE READINESS, DRUG EFFECTIVENESS AND THERAPEUTICAL FAILURES

The paper starts with a review of the research of the pathogenesis of HIV and its interplay with the study of mathematical models. Advances are then highlighted on model identifiability, identification techniques and the applications to current biomedical research and up-to-date clinical practise. An identifiability study is an answer to problems of what quantities and how frequently to measure in blood plasma. Parameter identification methods are chosen and developed for sparse and rough samples. Results are reported on two case studies: vaccine readiness in Southern Africa, drug effectiveness and therapy failures on existing patients in France. Ongoing research programmes and future opportunities are pointed out.