کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
727101 | 892685 | 2011 | 6 صفحه PDF | دانلود رایگان |
It is estimated that more than 95% of new drug candidates suffer from limited bioavailability [1]. Particle size reduction and formation of amorphous form are commonly used techniques in modifying bioavailability of such drugs. In the present study, electrospraying was used in drug particle production. Three poorly soluble drugs were electrosprayed. Particle size was reduced down to micrometre range. Electrospraying was carried out in both atmospheric and reduced pressure, the latter in order to increase the proportion of amorphous content. The aim of the study was to examine the degree of crystallinity of the produced particles for both pressures.
► Electrospraying was used in drug particle production.
► Electrospraying was carried out both in atmospheric and reduced pressure.
► The size distribution and crystallinity of the produced particles were studied.
► The pressure reduction increases the amount of amorphous product to a certain extent.
► The solubility of poorly soluble drugs may be improved by electrospraying.
Journal: Journal of Electrostatics - Volume 69, Issue 4, August 2011, Pages 351–356