کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7307875 | 1475382 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
l-rhamnose as a source of colonic propionate inhibits insulin secretion but does not influence measures of appetite or food intake
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کلمات کلیدی
VASFFARIAUCSCFAPYYGLP-1AUC - AUCl-rhamnose - l-rahamnoseshort-chain fatty acid - اسید چرب کوتاه مدتShort-chain fatty acids - اسیدهای چرب کوتاه مدتAppetite - اشتهاSatiety - خوشبختیInulin-type fructans - فروکتان نوعی اینولینEnergy intake - مصرف انرژی visual analogue scale - مقیاس آنالوگ بصریarea under curve - منطقه تحت منحنیHOMA - هومpeptide YY - پپتید YYfree fatty acid receptor - گیرنده اسید چرب آزاد
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Activation of free fatty acid receptor (FFAR)2 and FFAR3 via colonic short-chain fatty acids, particularly propionate, are postulated to explain observed inverse associations between dietary fiber intake and body weight. Propionate is reported as the predominant colonic fermentation product from l-rhamnose, a natural monosaccharide that resists digestion and absorption reaching the colon intact, while effects of long-chain inulin on appetite have not been extensively investigated. In this single-blind randomized crossover study, healthy unrestrained eaters (n = 13) ingested 25.5 g/d l-rhamnose, 22.4 g/d inulin or no supplement (control) alongside a standardized breakfast and lunch, following a 6-d run-in to investigate if appetite was inhibited. Postprandial qualitative appetite, breath hydrogen, and plasma glucose, insulin, triglycerides and non-esterified fatty acids were assessed for 420 min, then an ad libitum meal was provided. Significant treatment x time effects were found for postprandial insulin (P = 0.009) and non-esterified fatty acids (P = 0.046) with a significantly lower insulin response for l-rhamnose (P = 0.023) than control. No differences between treatments were found for quantitative and qualitative appetite measures, although significant treatment x time effects for meal desire (P = 0.008) and desire to eat sweet (P = 0.036) were found. Breath hydrogen was significantly higher with inulin (P = 0.001) and l-rhamnose (P = 0.009) than control, indicating colonic fermentation. These findings suggest l-rhamnose may inhibit postprandial insulin secretion, however neither l-rhamnose or inulin influenced appetite.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Appetite - Volume 98, 1 March 2016, Pages 142-149
Journal: Appetite - Volume 98, 1 March 2016, Pages 142-149
نویسندگان
Julia Darzi, Gary S. Frost, Jonathan R. Swann, Adele Costabile, M. Denise Robertson,