کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
736585 893878 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel micro-fabricated thruster for drug release in remote controlled capsule
موضوعات مرتبط
مهندسی و علوم پایه شیمی الکتروشیمی
پیش نمایش صفحه اول مقاله
A novel micro-fabricated thruster for drug release in remote controlled capsule
چکیده انگلیسی

A novel solid propellant microthruster has been developed and used as the actuation assembly of a patented remote controlled capsule (RCC). It produces sufficient gas pressure to empty the drug reservoir within the RCC. A MEMS-based microigniter works as the critical component of the miniaturized thruster that houses the detonating agent – diazodintrophenol (DDNP) and the propellant – black powder. Ignition and combustion tests were performed to justify its feasibility and reliability. Results demonstrated that 166 mW power consumption led to one successful combustion and that complete and rapid drug release was achieved when the propellant ranged from 16 mg to 20 mg. The RCC integrated with the microthruster could provide a promising alternative for site-specific drug delivery in human GI tract.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators A: Physical - Volume 159, Issue 2, May 2010, Pages 227–232
نویسندگان
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