کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
737203 1461889 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Performance improvement and functionalization of an electrode array for retinal prosthesis by iridium oxide coating and introduction of smart-wiring technology using CMOS microchips
موضوعات مرتبط
مهندسی و علوم پایه شیمی الکتروشیمی
پیش نمایش صفحه اول مقاله
Performance improvement and functionalization of an electrode array for retinal prosthesis by iridium oxide coating and introduction of smart-wiring technology using CMOS microchips
چکیده انگلیسی

The improvement of an electrode array for retinal prosthesis is described. Two elements of fundamental technology required in next-generation retinal prosthesis, the miniaturization of and wiring of a stimulus electrode, were investigated. To miniaturize the stimulus electrode without performance degradation, surface coating by iridium oxide (IrOx), a high performance material, was introduced. The electrochemical properties and durability of an IrOx coated electrode were evaluated through in vitro and in vivo experimentation. Results showed that IrOx coating delivers a higher performance with sufficient durability and contributes to the miniaturization of the electrode without degrading the stimulus capability. Smart-wiring technology using CMOS microchips was also investigated. A prototype electrode array with CMOS microchips was fabricated to clarify the concept. A dedicated CMOS microchip was hybrid-integrated into a stimulus electrode array. Results of in vivo experiments showed that the fabricated array stimulated retinal cells effectively. Miniaturized electrodes with an IrOx coating and smart-wiring technology enable the fabrication of a super-multi-channel (i.e., more than 1000) electrode array, which is required for next-generation retinal prosthesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators A: Physical - Volume 211, 1 May 2014, Pages 27–37
نویسندگان
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