کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
737849 1461923 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bubble time-of-flight: A simple method for measuring microliter per minute flows without calibration
موضوعات مرتبط
مهندسی و علوم پایه شیمی الکتروشیمی
پیش نمایش صفحه اول مقاله
Bubble time-of-flight: A simple method for measuring microliter per minute flows without calibration
چکیده انگلیسی

Monitoring liquid flow at microliter per minute (μL/min) rates is important for many lab-on-a-chip applications. Several technologies have been investigated to achieve this resolution, most of which require expensive detection systems and extensive calibration. Those technologies also rely on phenomena impacted by diffusion (e.g., heat pulses) that quickly lose accuracy as flow rates decrease. An alternative method, bubble time-of-flight, surmounts the limitations of diffusion by tracking the flow with bubbles. This method also has the advantage of not requiring calibration or complex sensing circuitry to accurately measure flow rates. We demonstrate this method with a device that uses thermoresisitive sensors to detect the passage of bubbles between two points. This device is able to measure flows from 100 to 1 μL/min. The accuracy of the system increases as flow rates decrease such that the low end uncertainty is 1% (±0.01 μL/min). We also demonstrate the feasibility of measurements in the sub 100 nL/min range by using a single sensor.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators A: Physical - Volume 177, April 2012, Pages 60–66
نویسندگان
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