A selective and sensitive voltammetric sensor based on molecularly imprinted polymer for the determination of dipyridamole in pharmaceuticals and biological fluids

This study introduces a selective and sensitive method for the determination of dipyridamole (DIP) using differential pulse adsorptive stripping voltammetry (DPASV). This method is based on the electrochemical behavior of DIP at a molecularly imprinted polymer (MIP) modified carbon paste electrode. The modified electrode demonstrated a linear response in the range of 1.0–110 ng mL−1 of DIP with a detection limit of 0.05 ng mL−1 under optimal conditions. The proposed method was applied to the DIP determination in tablet and human serum samples and results were satisfying compared with that obtained by HPLC.