One novel chemiluminescence sensor for determination of fenpropathrin based on molecularly imprinted porous hollow microspheres

In this paper, a novel chemiluminescence–molecular imprinting (CL–MI) sensor for determination of fenpropathrin in foodstuff has been developed. Fenpropathrin-imprinted porous hollow microspheres (FIPHMs) were prepared using mesoporous silica particles as cores. The mesoporous silica particles were modified by 3-Aminopropyltrimethoxysilane (APTS) and acrylyl chloride, respectively, and coated with a tunable thickness layer of template molecules and functional monomer by precipitation polymerization. The cores were finally dissolved to form the hollow structure of FIPHMs. The specific hollow structure made FIPHMs have highly dense of effective binding sites at both internal and external surfaces which enhanced its adsorption abilities and enrichment towards fenpropathrin molecule. The CL–MI flow sensor was built by packing the FIPHMs into a self-made polymethyl methacrylate flow cell. Tests showed that the prepared sensor achieved high sensitivity and selectivity. Under the optimal conditions, the relative CL intensity was linear with fenpropathrin concentration from 5.0 × 10−8 to 1.5 × 10−5 g mL−1 and with a detection limit of 3.07 × 10−8 g mL−1. The novel sensor has been successfully applied to the determination of fenpropathrin in food samples.