A novel sensitive and selective nanocomposite sensor for Doxorubicin based on Graphene Oxide and fluorescent [2]Rotaxane

• A novel sensitive and selective nanocomposite sensor for Doxorubicin based on Graphene Oxide and fluorescent [2]Rotaxane is developed.
• The quencher properties of GO are analyzed by UV–vis and fluorescence spectra.
• Fluorescence recovery can be observed after the addition of DOX.
• The results of the fluorescence analysis demonstrate that the RhBPy-GO sensor exhibits high sensitivity and selectivity toward DOX alone among many other antibiotics.

Graphene oxide (GO) displays advantageous characteristics as a quencher due to its excellent quenching capacity toward organic fluorescent molecules. In this paper, GO is used as a quencher of RhBPy [2]rotaxane based on the mechanism of fluorescence resonance energy transfer (FRET), and a GO-based fluorescent probe that allows rapid, sensitive and selective detection of doxorubicin (DOX) in a MeOH/H2O solution is reported. The results show that the efficient fluorescence quenching that occurs between GO and RhBPy [2]rotaxane is due to their strong noncovalent interactions via energy transfer, leading to very weak emission in the absence of DOX, while a strong red fluorescence is observed upon the addition of DOX into the RhBPy-GO solution. As a consequence, it is possible to employ the RhBPy-GO platform in DOX detection with high sensitivity and selectivity by monitoring changes in the fluorescence intensity of the MeOH/H2O (3:2, v: v) solution.

A novel sensitive and selective nanocomposite sensor for Doxorubicin based on Graphene Oxide and fluorescent [2]Rotaxane is developed. The results show high sensitivity and selectivity toward DOX among many other antibiotics in the MeOH/H2O (3:2, v:v) solution.Figure optionsDownload as PowerPoint slide