کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
743796 | 894371 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
SPICE macromodel of silicon-on-insulator-field-effect-transistor-based biological sensors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A user-friendly behavioral macromodel for biological response of FET-based transistors has been developed for use with commercial SPICE versions and will enable circuit level analysis of biosensor chips. The model is based on the physically realistic representation of biological layers using an ion-permeable charged membrane model. Simulations demonstrate good agreement to experimental results. Logarithmic increments in bound membrane charge result in linear threshold voltage shifts. The model accounts for phenomena such as Debye screening of biomolecules resulting in reduced sensor response to increments in salt concentration. Additionally, the presence of site binding charge on oxide surfaces is shown to severely deteriorate sensitivity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 161, Issue 1, 3 January 2012, Pages 163–170
Journal: Sensors and Actuators B: Chemical - Volume 161, Issue 1, 3 January 2012, Pages 163–170
نویسندگان
Poornika G. Fernandes, Harvey J. Stiegler, Mingyue Zhao, Kurtis D. Cantley, Borna Obradovic, Richard A. Chapman, Huang-Chun Wen, Gazi Mahmud, Eric M. Vogel,